The CCAIS was established pursuant to the CNU Board of Regents resolution No. 123 s 2023 on 6 September 2023. The said resolution subdivided the previous College of Arts and Sciences (CAS) into three Colleges namely: (1) the College of Law, Public Governance and Safety, (2) The College of Culture, Arts, and Sports, and (3) the College of Computing, Artificial Intelligence, and Sciences.

The division of CAS into three colleges was one of the initiatives of Dr. Daniel A. Ariaso Sr., the CNU 6th President, upon his assumption of Office on August 2023. The CAS was established in 1985 but was abolished in 1987 and was again restored in 1995.

The CCAIS is established based on Section 1 of Article XIV of the Philippine Constitution mandates that the State shall protect and promote the right of all citizens to quality education at all levels and shall take appropriate steps to make such education accessible to all.

This is also in accordance with Section 5 (2) of the same Article which guarantees the enjoyment of academic freedom in all institutions of higher learning.

Additionally, Section 1 of Republic Act No. 8248, an amendment of Section 4 of Republic Act 7687 by adding subsection 4-A, expressly authorizes the Science and Technology Human Resource Development Council “to formulate policies on advanced degree programs for science and technology [Subsection 4-A (4)] and to formulate programs to train and retrain scientist, engineers, researchers and technologists and encourage them through various incentives, to return and practice their professions in the Philippines, to enhance and accelerate the technological development of the country [Subsection 4-A (6)]”.